The TORC1-Nem1/Spo7-Pah1/lipin axis regulates microautophagy induction in budding yeast.
Identifieur interne : 000457 ( Main/Exploration ); précédent : 000456; suivant : 000458The TORC1-Nem1/Spo7-Pah1/lipin axis regulates microautophagy induction in budding yeast.
Auteurs : Muhammad Arifur Rahman [Japon] ; Mashu Terasawa [Japon] ; Md Golam Mostofa [Japon] ; Takashi Ushimaru [Japon]Source :
- Biochemical and biophysical research communications [ 1090-2104 ] ; 2018.
Descripteurs français
- KwdFr :
- Autophagie (MeSH), Complexes de tri endosomique requis pour le transport (métabolisme), Facteurs de transcription (métabolisme), Lipides (composition chimique), Métabolisme lipidique (MeSH), Phosphatidate phosphatase (métabolisme), Protéines de Saccharomyces cerevisiae (métabolisme), Protéines membranaires (métabolisme), Protéines nucléaires (métabolisme), Saccharomyces cerevisiae (métabolisme), Saccharomycetales (MeSH), Sirolimus (composition chimique).
- MESH :
- composition chimique : Lipides, Sirolimus.
- métabolisme : Complexes de tri endosomique requis pour le transport, Facteurs de transcription, Phosphatidate phosphatase, Protéines de Saccharomyces cerevisiae, Protéines membranaires, Protéines nucléaires, Saccharomyces cerevisiae.
- Autophagie, Métabolisme lipidique, Saccharomycetales.
English descriptors
- KwdEn :
- Autophagy (MeSH), Endosomal Sorting Complexes Required for Transport (metabolism), Lipid Metabolism (MeSH), Lipids (chemistry), Membrane Proteins (metabolism), Nuclear Proteins (metabolism), Phosphatidate Phosphatase (metabolism), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (metabolism), Saccharomycetales (MeSH), Sirolimus (chemistry), Transcription Factors (metabolism).
- MESH :
- chemical , chemistry : Lipids, Sirolimus.
- chemical , metabolism : Endosomal Sorting Complexes Required for Transport, Membrane Proteins, Nuclear Proteins, Phosphatidate Phosphatase, Saccharomyces cerevisiae Proteins, Transcription Factors.
- metabolism : Saccharomyces cerevisiae.
- Autophagy, Lipid Metabolism, Saccharomycetales.
Abstract
Nutrient starvation and inactivation of target of rapamycin complex 1 (TORC1) protein kinase promotes macroautophagy. Macroautophagy is a lipid-consuming process, and Nem1/Spo7 protein phosphatase and Pah1/lipin phosphatidate phosphatase are activated after TORC1 inactivation, supporting macroautophagy induction in the budding yeast Saccharomyces cerevisiae. On the other hand, whether and how microautophagy, which also consumes lipids, is regulated by TORC1 is controversial. Here we show that TORC1 inactivation induces microautophagy in budding yeast. Vps27, but not Atg1, Atg7, or Atg8, was required for TORC1 inactivation-induced microautophagy. Furthermore, the Nem1/Spo7-Pah1 axis was also critical for microautophagy induction. Thus, the TORC1-Nem1/Spo7-Pah1 axis is a master regulator of not only macroautophagy but also microautophagy in budding yeast.
DOI: 10.1016/j.bbrc.2018.09.011
PubMed: 30201264
Affiliations:
Links toward previous steps (curation, corpus...)
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Macroautophagy is a lipid-consuming process, and Nem1/Spo7 protein phosphatase and Pah1/lipin phosphatidate phosphatase are activated after TORC1 inactivation, supporting macroautophagy induction in the budding yeast Saccharomyces cerevisiae. On the other hand, whether and how microautophagy, which also consumes lipids, is regulated by TORC1 is controversial. Here we show that TORC1 inactivation induces microautophagy in budding yeast. Vps27, but not Atg1, Atg7, or Atg8, was required for TORC1 inactivation-induced microautophagy. Furthermore, the Nem1/Spo7-Pah1 axis was also critical for microautophagy induction. Thus, the TORC1-Nem1/Spo7-Pah1 axis is a master regulator of not only macroautophagy but also microautophagy in budding yeast.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30201264</PMID><DateCompleted><Year>2019</Year><Month>03</Month><Day>25</Day></DateCompleted><DateRevised><Year>2019</Year><Month>03</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2104</ISSN><JournalIssue CitedMedium="Internet"><Volume>504</Volume><Issue>2</Issue><PubDate><Year>2018</Year><Month>10</Month><Day>02</Day></PubDate></JournalIssue><Title>Biochemical and biophysical research communications</Title><ISOAbbreviation>Biochem Biophys Res Commun</ISOAbbreviation></Journal><ArticleTitle>The TORC1-Nem1/Spo7-Pah1/lipin axis regulates microautophagy induction in budding yeast.</ArticleTitle><Pagination><MedlinePgn>505-512</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0006-291X(18)31921-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbrc.2018.09.011</ELocationID><Abstract><AbstractText>Nutrient starvation and inactivation of target of rapamycin complex 1 (TORC1) protein kinase promotes macroautophagy. Macroautophagy is a lipid-consuming process, and Nem1/Spo7 protein phosphatase and Pah1/lipin phosphatidate phosphatase are activated after TORC1 inactivation, supporting macroautophagy induction in the budding yeast Saccharomyces cerevisiae. On the other hand, whether and how microautophagy, which also consumes lipids, is regulated by TORC1 is controversial. Here we show that TORC1 inactivation induces microautophagy in budding yeast. Vps27, but not Atg1, Atg7, or Atg8, was required for TORC1 inactivation-induced microautophagy. Furthermore, the Nem1/Spo7-Pah1 axis was also critical for microautophagy induction. Thus, the TORC1-Nem1/Spo7-Pah1 axis is a master regulator of not only macroautophagy but also microautophagy in budding yeast.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rahman</LastName><ForeName>Muhammad Arifur</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Terasawa</LastName><ForeName>Mashu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mostofa</LastName><ForeName>Md Golam</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ushimaru</LastName><ForeName>Takashi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Graduate School of Science and Technology, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan; Department of Science, Shizuoka University, Ohya 836, Suruga-ku, Shizuoka, 422-8021, Japan. Electronic address: ushimaru.takashi@shizuoka.ac.jp.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>09</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biochem Biophys Res Commun</MedlineTA><NlmUniqueID>0372516</NlmUniqueID><ISSNLinking>0006-291X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D056827">Endosomal Sorting Complexes Required for Transport</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008055">Lipids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C502372">Nem1 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009687">Nuclear Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C116365">SPO7 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C561842">TORC1 protein complex, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C119627">VPS27 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.3.4</RegistryNumber><NameOfSubstance UI="C079831">PAH1 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.3.4</RegistryNumber><NameOfSubstance UI="D010711">Phosphatidate Phosphatase</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="Y">Autophagy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056827" MajorTopicYN="N">Endosomal Sorting Complexes Required for Transport</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050356" MajorTopicYN="N">Lipid Metabolism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008055" MajorTopicYN="N">Lipids</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008565" MajorTopicYN="N">Membrane Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009687" MajorTopicYN="N">Nuclear Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010711" MajorTopicYN="N">Phosphatidate Phosphatase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004718" MajorTopicYN="N">Saccharomycetales</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Lipin</Keyword><Keyword MajorTopicYN="Y">Microautophagy</Keyword><Keyword MajorTopicYN="Y">Nem1</Keyword><Keyword MajorTopicYN="Y">Pah1</Keyword><Keyword MajorTopicYN="Y">Rapamycin</Keyword><Keyword MajorTopicYN="Y">Target of rapamycin complex 1 (TORC1)</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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Muhammad Arifur" uniqKey="Rahman M" first="Muhammad Arifur" last="Rahman">Muhammad Arifur Rahman</name></noRegion><name sortKey="Mostofa, Md Golam" sort="Mostofa, Md Golam" uniqKey="Mostofa M" first="Md Golam" last="Mostofa">Md Golam Mostofa</name><name sortKey="Terasawa, Mashu" sort="Terasawa, Mashu" uniqKey="Terasawa M" first="Mashu" last="Terasawa">Mashu Terasawa</name><name sortKey="Ushimaru, Takashi" sort="Ushimaru, Takashi" uniqKey="Ushimaru T" first="Takashi" last="Ushimaru">Takashi Ushimaru</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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